Frequently Asked Questions

FontUp® is a food supplement containing epigallocatechin-3-gallate (EGCG), a compound derived from green tea extract that has demonstrated improvements in cognitive performance in individuals with subjective cognitive decline.

Subjective cognitive decline (SCD) refers to the personal perception of reduced cognitive performance (such as memory or attention), despite no abnormalities being detected in medical evaluations and no impact on daily life. 

It often manifests as more frequent forgetfulness, feeling mentally scattered, or receiving comments from others about small changes that the person might not notice themselves. 

There is growing evidence that SCD may represent an early stage in the cognitive decline process, and that some individuals with SCD are at higher risk of developing more advanced cognitive problems such as dementia or Alzheimer’s disease. 

Epigallocatechin-3-gallate (EGCG) is a natural polyphenol found in green tea. Various studies have explored its potential benefits in brain aging and cognitive balance. FontUp® offers a concentrated and highly absorbable version. 

FontUp® has been evaluated in the PENSA study, a clinical trial involving over 100 individuals with subjective cognitive decline and genetic risk of Alzheimer’s (carriers of the APOE-e4 allele). 

Over a 12-month period, the trial assessed the impact of a multimodal lifestyle intervention (nutrition, physical activity, cognitive stimulation, and social interaction) combined with FontUp® supplementation. 

Participants who took FontUp® showed improvements in cognitive functions such as memory and executive function, and a reduced risk of dementia. The study was published in The Journal of Prevention of Alzheimer’s Disease. 

Although the mechanisms are still being studied, EGCG appears to support processes related to synaptic plasticity. 

In experimental models, EGCG has shown the ability to influence cellular pathways involved in synaptic function, oxidative stress, and the accumulation of proteins such as β-amyloid and phosphorylated tau — elements linked to cognitive decline in neurodegenerative diseases like Alzheimer’s. 

Additionally, preclinical studies suggest EGCG may enhance cognitive performance, improve learning capacity, and reduce oxidative stress — all relevant in early stages of cognitive decline. 

FontUp® contains a specially formulated version of EGCG to enhance absorption and has been used as part of early intervention strategies in clinical studies like PENSA, focusing on people with SCD. 

Singh NA, Mandal AKA, Khan ZA. Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG). Nutr J. 2016;15(1):60. 
Amin MA, Zehravi M, et al. Neuroprotective potential of EGCG in Neurodegenerative Diseases. Brain Res. 2025;1860:149693. 
DOI: http://dx.doi.org/10.1016/j.brainres.2025.149693 

The clinical dose used was 10 mg of EGCG per kg of body weight per day. For an adult, the recommended dose is 5 capsules daily, ideally distributed as follows: 2 with breakfast, 1 with lunch, and 2 with dinner (2-1-2 scheme). 

Yes. However, it is recommended to distribute the dose throughout the day to maintain more stable blood levels of EGCG, as long as it is taken daily. 

According to clinical studies, the effects of EGCG may begin to show after the first 6 months of treatment, especially when combined with a healthy lifestyle (nutrition, exercise, cognitive stimulation, and social interaction).

FontUp®’s benefits are observed while the supplement is being taken. Its continued use has been shown to be safe (based on results from the PENSA study), although medical supervision is recommended during use. 

FontUp®’s benefits are observed while the supplement is being taken. Its continued use has been shown to be safe (based on results from the PENSA study), although medical supervision is recommended during use. 

Yes. There is no interaction between EGCG and food, so the capsule content can be mixed with yogurt, a smoothie, or any food of your choice. Please note that green tea is naturally very bitter, so the contents may have a strong bitter taste. 

According to the PENSA study, the best results with FontUp® were achieved when combined with a healthy diet, regular exercise, and cognitive stimulation. There is a synergistic effect between EGCG supplementation and multimodal lifestyle intervention.